Stanford University
Molecular Pharmacology Dept.
QCB Program
Bio-X
 

Ouyang, X., Shestopalov, I. A., Sinha, S., Zheng, G., Pitt, C. L. W., Li, W.-H., Olson, A. J., and Chen, J. K. (2009) Versatile synthesis and rational design of caged morpholinos. J. Am. Chem. Soc. 131: 13255-13269. [PubMed]

Hyman, J. M., Firestone, A. J., Heine, V. M., Zhao, Y., Ocasio, C. A., Han, K., Sun, M., Rack, P. G., Sinha, S., Wu, J. J., Solow-Cordero, D. E., Jiang, J., Rowitch, D. H., and Chen, J. K. (2009) Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proc. Natl. Acad. Sci. U. S. A., 106:14132-14137. [PubMed]

Yang, H., Xiang, J., Wang, N., Zhao, Y., Hyman, J., Jiang, J., Chen, J. K., Yang, Z., and Lin, S. (2009) Converse conformational control of Smoothened activity by structurally related small molecules. J. Biol. Chem. 284: 20876-20884. [PubMed]

Cupido, T., Rack, P. G., Firestone, A. J., Hyman, J. M., Han, K., Sinha, S., Ocasio, C. A, and Chen, J. K. (2009) The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling. Angew. Chemie Intl. Ed. 48: 2321-2324. [PubMed]

Mich, J.K., Blaser, H., Thomas, N. A., Firestone, A. J., Yelon, D., Raz, E., and Chen, J. K. (2009) Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Dev. Biol. 328: 342-354. [PubMed]

Stanton, B. Z., Peng, L. F., Maloof, N., Nakai, K., Wang, X., Herlihy, K. M., Duffner, J. L., Taveras, K. M., Hyman, J. M., Lee, S. W., Koehler, A. N., Chen, J. K., Fox, J. L., Mandinova, A., and Schreiber, S. L. (2009) A small molecule that binds Hedgehog and blocks its signaling in human cells. Nat. Chem. Biol. 5: 154-156. [PubMed]

Low, W.-C., Wang, C., Pan, Y., Huang, X.-Y., Chen, J. K., and Wang, B. (2008) The decoupling of Smoothened from G-alpha-i proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Dev. Biol. 321: 188-196. [PubMed]

Shestopalov, I. A. and Chen, J. K. (2008) Chemical technologies for probing embryonic development. Chem. Soc. Rev. 37: 1294-1307. [PubMed]

Esengil, H. and Chen, J. K. (2008) Gene regulation technologies for zebrafish. Mol. BioSystems 4: 300-308. [PubMed]

Shestopalov, I., Sinha, S., and Chen, J. K. (2007) Light-controlled gene silencing in zebrafish embryos.
Nat. Chem. Biol. 3: 650-651. [PubMed]

Esengil, H., Chang, V., Mich, J. K., and Chen, J. K. (2007) Small-molecule regulation of zebrafish gene expression. Nat. Chem. Biol. 3: 154-155. [PubMed]

Meloni, A. R., Fralish, G. B., Kelly, P., Salahpour, A., Chen, J. K., Wechsler-Reya, R. J., Lefkowitz, R. J. and Caron, M. G. (2006) Smoothened signal transduction is promoted by G-protein coupled receptor kinase 2.  Mol. Cell. Biol. 26: 7550-7560. [PubMed]

Sinha, S. and Chen, J.K. (2006) Purmorphamine activates the Hedgehog pathway by targeting Smoothened. Nat. Chem. Biol. 2: 29-30. [PubMed]

Chen, W., Ren, X., Nelson, C. D, Barak, L. S., Chen, J. K., Beachy, P. A., de Sauvage, F., and Lefkowitz, R. J. (2004) Activity-dependent internalization of Smoothened mediated by beta-Arrestin 2 and GRK2. Science 306: 2257-2260. [PubMed]

Chen, J. K., Taipale, J., Young, K. E., Maiti, T., and Beachy, P. A. (2002) Small molecule modulation of Smoothened activity. Proc. Natl. Acad. Sci. U. S. A. 99: 14071-14076. [PubMed]

Chen, J. K., Taipale, J., Cooper, M. K., and Beachy, P. A. (2002) Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 16: 2743-2748. [PubMed]

Berman, D. M., Karhadkar, S. S., Hallahan, A. R. Pritchard, J. I., Eberhart, C. G., Watkins, D. N., Chen, J. K., Cooper, M. K., Taipale, J., Olson, J. M., and Beachy, P. A. (2002) Medulloblastoma growth inhibition by Hedgehog pathway blockade. Science 297: 1559-1561. [PubMed]

Taipale, J., Chen, J. K., Cooper, M. K., Wang, B., Mann, R. K., Milenkovic, L., Scott, M. P., and Beachy, P. A. (2000) The effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406: 1005-1009. [PubMed]